Acetic Acid → HCID 178512520, compound

Participants

Reaction Steps

A solution of 1 g of benzyl 4-(4-(4-(3-CBZ-guanidino)benzoyl)piperazin-1-yl)butyrate (FAB 558; obtainable by condensing 4-(3-CBZ-guanidino)benzoic acid with benzyl 4-(piperazin-1-yl)butyrate) in a mixture of 38 ml of methanol, 6 ml of water and 6 ml of acetic acid is hydrogenated on 0.6 g of 5% Pd/C at 20° and 1 bar until the uptake of H2 has ceased. It is filtered, the filtrate is evaporated and the residue is recrystallized from ethyl acetate to give 4-(4-(4-guanidinobenzoyl)piperazin-1-yl)butyric acid, FAB 334.

Provenance & Evidence