HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (piperazin-1-yl)acetate → HCID 53864541, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (piperazin-1-yl)acetate | HCID 2757326 | — |
| Reactant | HCID 9821029 | HCID 9821029 | — |
| Reactant | HCID 53812397 | HCID 53812397 | — |
| Reactant | Benzyl [amino(methylsulfanyl)methylene]carbamate | HCID 140362141 | — |
| Product | HCID 53864541 | HCID 53864541 | — |
Reaction Steps
3-(3-(4-amidinopiperazin-1-ylacetamido)benzamido)propionic acid, m.p. 270° (decomposition), from benzyl 3-(3-(4-CBZ-amidinopiperazin-1-ylacetamido)benzamido)propionate (FAB 601; obtainable by reacting tert-butyl piperazin-1-ylacetate with N-CBZ-S-methylisothiourea to give tert-butyl 4-CBZ-amidinopiperazin-1-ylacetate, cleaving the tert-butyl group with 4 N HCl in dioxane and condensing the resulting 4-CBZ-amidinopiperazin-1-ylacetic acid with benzyl 3-(3-aminobenzamido)propionate);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05908843 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-90bdff9b7c8a4264b06d3c5f7ba2c8b9 |
| Source note | uspto-grants-1999_06 |