Hydrochloric Acid → HCID 53880824, compound

Participants

Reaction Steps

A solution of Li--N(Si(CH3)3)2 in 20 ml of THF, freshly prepared from C4H9Li and 1.13 g of hexamethyldisilazane, is added dropwise at -78°, with stirring, to a solution of 3.15 g of ethyl 3-(4-(4-cyanobenzoyl)piperazin-1-yl)propionate (FAB 316; obtainable by reacting 4-cyanobenzoyl chloride with ethyl piperazin-1-ylpropionate) in 50 ml of THF. The mixture is left to warm up to 20°, with stirring, aqueous hydrochloric acid is added, the mixture is washed with ethyl acetate, sodium hydroxide solution is added to pH 7.5 and the mixture is worked up in conventional manner and evaporated to give ethyl 3-(4-(4-amidinobenzoyl)piperazin-1-yl)propionate, FAB 333.

Provenance & Evidence