Sodium Carbonate → HCID 86754083, compound

Participants

Reaction Steps

A mixture of N-[2-(dimethylamino)ethyl]-2-iodo-11-oxo-11H-pyrido[2,1-b]quinazoline-6-carboxamide (100 mg), 3-pyridinyl-boronic acid (225.41 mg), tetrakis(tri-phenylphosphine)palladium(0) (66.22 mg) and sodium carbonate (0.57 ml of 2 M (1.15 mmol)) was heated in an oil bath at 120° C.-125° C. for 45 minutes. The reaction mixture was cooled to room temperature, diluted with water (30 ml), and extracted with CH2Cl2 (3×30 ml). Combined organic phases were washed with brine (50 ml), dried with MgSO4, filtered and concentrated in vacuo. The residue was purified on SiO2 (50 g; gradient elution with 10-30% MeOH/CHCl3) to give the desired product (66 mg).

Provenance & Evidence