Dimethyl Sulfate → HCID 86754084, compound

Participants

Reaction Conditions

Reaction Steps

To a heated (90° C.), stirred solution of 7,8-dimethoxy4-oxo-3,4,5,10-tetrahydropyrimido[4,5-b]quinoline (0.25 g, 0.96 mmol) and sodium hydroxide (0.05 g, 1.25 mmol) in water (3 mL) was added dimethylsulfate (0.23 mL, 2.4 mmol). After 0.5 hour, the reaction mixture was diluted with water (20 mL), the solids filtered, washed with acetonitrile and dried in vacuo to afford 0.13 g of the title compound; m.p. 225-230° C.

Provenance & Evidence