Acrolein → HCID 21862815, compound

HRID 1415745Notes

Reaction equation

HRID 1415745 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([NH:6][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16](=[O:19])(=[O:18])[NH2:17])=[CH:12][CH:11]=2)[C:8]#N)=[CH:4][CH:3]=1.[CH:22]([CH:24]=C)=O>>[F:1][C:2]1[CH:21]=[CH:20][C:5]([N:6]2[CH:24]=[CH:22][CH:8]=[C:7]2[C:10]2[CH:15]=[CH:14][C:13]([S:16](=[O:19])(=[O:18])[NH2:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7847AcroleinHCID 21862840HCID 21862840, compound

Product 1

HCID 21862815HCID 21862815, compound

Procedure

Following a procedure similar to that described in Example 1(iii), but using α-(4-fluoroanilino)-α-(4-sulfamoylphenyl)acetonitrile [prepared as described in step (ii) above] and acrolein as starting materials, the title compound was obtained as a white powder (yield 48%), melting at 160-161° C.

Sources & evidence

ORD record
ord-ab84de698ec844f3a49b4b5ae0083d26
Source dataset
uspto-grants-1999_06
Patent number
US05908858

Reaction notes

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