Methacrolein → HCID 21862883, compound

HRID 1415810Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19](=[O:22])(=[O:21])[NH2:20])=[CH:15][CH:14]=2)[C:10]#N)[CH:5]=[CH:6][C:7]=1[F:8].O=[CH:24][C:25](=C)[CH3:26]>>[F:1][C:2]1[CH:3]=[C:4]([C:9]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19](=[O:22])(=[O:21])[NH2:20])=[CH:15][CH:14]=3)[CH:24]=[C:25]([CH3:26])[CH:10]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

Reactant 2

HCID 6562Methacrolein

HCID 21862869HCID 21862869, compound

Product 1

HCID 21862883HCID 21862883, compound

Procedure

Following a procedure similar to that described in Example 1(iii), but using α-(3,4-difluorophenyl)-α-(4-sulfamoylanilino)acetonitrile [prepared as described in step (ii) above] and methacrolein as starting materials, the title compound was obtained as a pale yellow powder (yield 51%), melting at 177-1 79° C.

Sources & evidence

ORD record: ord-bda50dd4aab344818f645547fd189dbe
Source dataset: uspto-grants-1999_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05908858

Reaction notes

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