Methacrolein → 4-Methyl-1-(3,4-dimethylphenyl)-2-(4-sulfamoylphenyl)pyrrole

HRID 1415837Notes

Reaction equation

HRID 1415837 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:19]=[CH:20][C:21]=1[CH3:22])[NH:5][CH:6]([C:9]1[CH:14]=[CH:13][C:12]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:11][CH:10]=1)[C:7]#N.O=[CH:24][C:25](=C)[CH3:26]>>[CH3:26][C:25]1[CH:7]=[C:6]([C:9]2[CH:14]=[CH:13][C:12]([S:15](=[O:18])(=[O:17])[NH2:16])=[CH:11][CH:10]=2)[N:5]([C:4]2[CH:19]=[CH:20][C:21]([CH3:22])=[C:2]([CH3:1])[CH:3]=2)[CH:24]=1

Participants

3

Reactant 2

HCID 6562MethacroleinHCID 21862804alpha-(3,4-Dimethylanilino)-alpha-(4-sulfamoylphenyl)acetonitrile

Product 1

HCID 218628944-Methyl-1-(3,4-dimethylphenyl)-2-(4-sulfamoylphenyl)pyrrole

Procedure

Following a procedure similar to that described in Example 1(iii), but using α-(3,4-dimethylanilino)-α-(4-sulfamoylphenyl)acetonitrile [prepared as described in step (ii) above] and methacrolein as starting materials, the title compound was obtained as a slightly yellow powder (yield 43%), melting at 118-120° C.

Sources & evidence

ORD record
ord-20ffb65e8bda45b7b5abc9b20585cf57
Source dataset
uspto-grants-1999_06
Patent number
US05908858

Reaction notes

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