Methacrolein → 4-Methyl-2-(3,5-dimethylphenyl)-1-(4-sulfamoylphenyl)pyrrole

HRID 1415840Notes

Reaction equation

HRID 1415840 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([S:19](=[O:22])(=[O:21])[NH2:20])=[CH:15][CH:14]=2)[C:10]#N)[CH:5]=[C:6]([CH3:8])[CH:7]=1.O=[CH:24][C:25](=C)[CH3:26]>>[CH3:26][C:25]1[CH:10]=[C:9]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:7]=[C:6]([CH3:8])[CH:5]=2)[N:12]([C:13]2[CH:18]=[CH:17][C:16]([S:19](=[O:22])(=[O:21])[NH2:20])=[CH:15][CH:14]=2)[CH:24]=1

Participants

3

Reactant 2

HCID 6562MethacroleinHCID 21862823alpha-(3,5-Dimethylphenyl)-alpha-(4-sulfamoylanilino)acetonitrile

Product 1

HCID 218627584-Methyl-2-(3,5-dimethylphenyl)-1-(4-sulfamoylphenyl)pyrrole

Procedure

Following a procedure similar to that described in Example 1(iii), but using α-(3,5-dimethylphenyl)-α-(4-sulfamoylanilino)acetonitrile [prepared as described in step (ii) above] and methacrolein as starting materials, the title compound was obtained as a slightly brown powder (yield 28%), melting at 163-166° C.

Sources & evidence

ORD record
ord-cad39cc4bacb41ef8bd29dce30a684fd
Source dataset
uspto-grants-1999_06
Patent number
US05908858

Reaction notes

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