Hydrochloric Acid → HCID 54002154, compound

Participants

Reaction Steps

Bromine (18.6 g) was added to a solution of the product (10.4 g) from step (f) dissolved in glacial acetic acid (150 ml). The reaction mixture was stirred at room temperature for 2 hours. Acetic acid was removed in vacuo, added another 100 ml and concentrated in vacuo. The resulting residue was dissolved in EtOAc and washed with sodium metabisulfite and 1N NaOH. The organic layer was separated, dried and concentrated in vacuo to give a brown oil which was then converted to the hydrochloride salt with ethereal HCl. This solid was filtered, washed with ether and then treated with 1N NaOH and EtOAc to get the title product (8.9 g) as an orange oil. 1H NMR consistent with the proposed structure.

Provenance & Evidence