Water → HCID 86754092, compound

Participants

Reaction Steps

A mixture of (E,E,Z)-7-{3-[5-(tert-butyldimethylsilyloxy)pentyloxy]-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl}-3-methyl-2,4,6-octatrienoic acid (850 mg, 1.5 mmol) and a 1M solution in THF of tetrabutylammonium fluoride (TBAF) (3.1 ml) in THF (10 ml) was stirred at room temperature for 1 h and then treated with ethyl acetate and with water. After settling, the organic phase was separated and washed twice with water, dried over anhydrous magnesium sulfate and concentrated in a rotary evaporator under vacuum at 40° C.

Provenance & Evidence