Sulfuric Acid → 7-Chloro-6-fluoro-1-(2,4-difluoro-5-nitrophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

HRID 1415919Notes

Reaction equation

HRID 1415919 reaction equation
S(=O)(=O)(O)O.[Cl:6][C:7]1[N:16]=[C:15]2[C:10]([C:11](=[O:28])[C:12]([C:25]([OH:27])=[O:26])=[CH:13][N:14]2[C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:18]=2[F:24])=[CH:9][C:8]=1[F:29].[N+:30]([O-])([O-:32])=[O:31].[K+]>>[Cl:6][C:7]1[N:16]=[C:15]2[C:10]([C:11](=[O:28])[C:12]([C:25]([OH:27])=[O:26])=[CH:13][N:14]2[C:17]2[CH:22]=[C:21]([N+:30]([O-:32])=[O:31])[C:20]([F:23])=[CH:19][C:18]=2[F:24])=[CH:9][C:8]=1[F:29]

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24434Potassium NitrateHCID 105460847-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Product 1

HCID 158603627-Chloro-6-fluoro-1-(2,4-difluoro-5-nitrophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acidYield 94.7%

Procedure

To 25 ml of conc. sulfuric acid was added 6.0 grams of 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid. With ice cooling and stirring, to the solution was added 5.0 g of potassium nitrate in portions. The temperature was slowly elevated to 80° C. at which stirring was continued for 2 hours. The reaction solution was allowed to cool, poured into 200 g of ice water, and allowed to stand overnight. The precipitate was collected by filtration, washed with distilled water, ethanol and diisopropyl ether, and air dried, to give 6.4 g of the title compound.

Workup

  1. customwas slowly elevated to 80° C. at which
  2. stirringstirring
  3. temperatureto cool
  4. waitto stand overnight
  5. filtrationThe precipitate was collected by filtration
  6. washwashed with distilled water, ethanol and diisopropyl ether, and air
  7. customdried

Sources & evidence

ORD record
ord-338745e2cb284a8eb036b86186c1f386
Source dataset
uspto-grants-1999_06
Patent number
US05910498

Reaction notes

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