Potassium Nitrate → HCID 15860365, compound

HRID 1415922Notes

Reaction equation

HRID 1415922 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:18]2[C:13](=[CH:14][C:15]([F:21])=[C:16]([F:20])[C:17]=2[F:19])[C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10]1.[N+:26]([O-])([O-:28])=[O:27].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:26]([O-:28])=[O:27])=[CH:4][C:3]=1[N:9]1[C:18]2[C:13](=[CH:14][C:15]([F:21])=[C:16]([F:20])[C:17]=2[F:19])[C:12](=[O:22])[C:11]([C:23]([OH:25])=[O:24])=[CH:10]1

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 14476011HCID 14476011, compound

Product 1

HCID 15860365HCID 15860365, compoundYield 88.8%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
60 °C

Procedure

To 10 ml of conc. sulfuric acid was added 1.7 g of 1-(2,4-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. Potassium nitrate (1.5 g) was added in portions to the solution, which was heated at 60° C. and stirred overnight. The reaction solution was allowed to cool down, poured into ice water, and stirred overnight. The precipitated solid was collected by filtration and washed with water, ethanol and diethyl ether to give 1.7 g of the title compound.

Workup

  1. temperatureto cool down
  2. stirringstirred overnight
  3. filtrationThe precipitated solid was collected by filtration
  4. washwashed with water, ethanol and diethyl ether

Sources & evidence

ORD record
ord-84cb115618684925a4cc6ba6a0fd5288
Source dataset
uspto-grants-1999_06
Patent number
US05910498

Reaction notes

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