Potassium Nitrate → HCID 22441038, compound

HRID 1415923Notes

Reaction equation

HRID 1415923 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:24])[C:7]([C:21]([OH:23])=[O:22])=[CH:8][N:9]2[C:12]2[CH:17]=[CH:16][C:15]([F:18])=[C:14]([F:19])[C:13]=2[F:20])=[CH:4][C:3]=1[F:25].[N+:26]([O-])([O-:28])=[O:27].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([C:6](=[O:24])[C:7]([C:21]([OH:23])=[O:22])=[CH:8][N:9]2[C:12]2[CH:17]=[C:16]([N+:26]([O-:28])=[O:27])[C:15]([F:18])=[C:14]([F:19])[C:13]=2[F:20])=[CH:4][C:3]=1[F:25]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 57034019HCID 57034019, compound

Product 1

HCID 22441038HCID 22441038, compoundYield 86.2%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To 10 ml of conc. sulfuric acid was added 890 mg of 7-chloro-6-fluoro-1,4-dihydro-4-oxo-1-(2,3,4-trifluorophenyl)-1,8-naphthyridine-3-carboxylic acid. Potassium nitrate (730 mg) was added in portions to the solution, which was stirred at room temperature for 2 days. The reaction solution was allowed to cool, poured into ice water, and stirred overnight. The precipitated solid was collected by filtration, washed with water, ethanol and diethyl ether to give 860 mg of the title compound.

Workup

  1. temperatureto cool
  2. stirringstirred overnight
  3. filtrationThe precipitated solid was collected by filtration
  4. washwashed with water, ethanol and diethyl ether

Sources & evidence

ORD record
ord-713b20a4f7284f59a88d6f2a6dda89c7
Source dataset
uspto-grants-1999_06
Patent number
US05910498

Reaction notes

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