Potassium Nitrate → HCID 22441018, compound

HRID 1415924Notes

Reaction equation

HRID 1415924 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]([C:13]1[CH:18]=[CH:17][C:16]([F:19])=[C:15]([F:20])[C:14]=1[F:21])[CH:7]=[C:6]([C:22]([OH:24])=[O:23])[C:5]2=[O:25].[N+:26]([O-])([O-:28])=[O:27].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]([C:13]1[CH:18]=[C:17]([N+:26]([O-:28])=[O:27])[C:16]([F:19])=[C:15]([F:20])[C:14]=1[F:21])[CH:7]=[C:6]([C:22]([OH:24])=[O:23])[C:5]2=[O:25]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 54089117HCID 54089117, compound

Product 1

HCID 22441018HCID 22441018, compoundYield 74.9%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Conditions

Temperature
100 °C

Procedure

To 10 ml of conc. sulfuric acid was added 830 mg of 6,7-difluoro-1,4-dihydro-4-oxo-1-(2,3,4-trifluorophenyl)-quinoline-3-carboxylic acid. Potassium nitrate (710 mg) was added in portions to the solution, which was stirred at 100° C. for 3 days. The reaction solution was allowed to cool, poured into ice water, and stirred overnight. The precipitated solid was collected by filtration, washed with water, ethanol and diethyl ether to give 700 mg of the title compound.

Workup

  1. temperatureto cool
  2. stirringstirred overnight
  3. filtrationThe precipitated solid was collected by filtration
  4. washwashed with water, ethanol and diethyl ether

Sources & evidence

ORD record
ord-008c678f2a6844f68dd991beaa868cbb
Source dataset
uspto-grants-1999_06
Patent number
US05910498

Reaction notes

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