反应详情

温度

100 °C

1-(3-amino-4,6-difluorophenyl)-7-chloro-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (310 mg) was added to 920 mg of N,N-dimethylformamide together with 220 mg of benzoic anhydride, which was stirred at 70° C. for 2 hours and at 100° C. for 2.5 hours. The reaction solution was combined with 50 ml of chloroform and 150 ml of distilled water. The solution was separated, the chloroform layer was dried over anhydrous magnesium sulfate and concentrated in vacua. Ethanol (6 ml) was added to the residue, which was allowed to stand. The precipitate was collected by filtration and washed with ethanol and then with diisopropyl ether to give 184 mg of the title compound.

1. customThe solution was separated
2. dry with materialthe chloroform layer was dried over anhydrous magnesium sulfate
3. concentrationconcentrated in vacua
4. additionEthanol (6 ml) was added to the residue, which
5. filtrationThe precipitate was collected by filtration
6. washwashed with ethanol