Methanesulfonic Acid → HCID 86754101, compound

Participants

Reaction Steps

To 4 ml of ethanol were added 215 mg of 1-(3-amino-4,6-difluorophenyl)-6-fluoro-7-[(3S)-3-(L-valylamino)pyrrolidin-1-yl]-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid and 24 mg of methanesulfonic acid. The mixture was stirred and heated at reflux for 30 minutes. The solution was allowed to cool down and the precipitate was collected by filtration, washed with ethanol and then diisopropyl ether, and-air dried to give 211 mg of the title compound.

Provenance & Evidence