HCID 54231342, compound → HCID 23284779, compound

Participants

Reaction Conditions

Reaction Steps

To 5 ml of formic acid were added 1.5 g of ethyl 8-chloro-6,7-difluoro-1-(2-chloro-4-fluoro-5-nitrophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate and 2 g of iron. The solution was heated and stirred at 60° C. for 2 hours. The insoluble was removed by filtration through celite and washed with formic acid and chloroform. The filtrate was concentrated in vacua. Ethanol was added to the residue whereupon the solid was collected by filtration and washed with diethyl ether. To the solid were added 4 ml of conc. hydrochloric acid and 4 ml of acetic acid. The solution was heated at reflux for 1 hour and allowed to cool down. The precipitated was collected by filtration and washed with ethanol and diethyl ether to give 970 mg of the title compound.

Provenance & Evidence