Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Methylpyrrolidine | HCID 8454 | — |
| Reactant | Azetidin-3-amine--hydrogen chloride (1/2) | HCID 13491919 | — |
| Reactant | HCID 23284760 | HCID 23284760 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Diisopropyl Ether | HCID 7914 | — |
| Product | HCID 53690243 | HCID 53690243 | 153.4% |
Reaction Steps
To 650 mg of N,N-dimethylformamide were added 150 mg of 1-(3-methylamino-4,6-difluorophenyl)-8-chloro-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 110 mg of 3-aminoazetidine dihydrochloride, and 250 mg of N-methylpyrrolidine. The solution was stirred at 90° C. for 1 hour. After 0.5 ml of ethanol was added, the reaction solution was allowed to cool down. The precipitate was collected by filtration and washed with ethanol and then diisopropyl ether to give 130 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05910498 |
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| Source dataset | uspto-grants-1999_06 |
|---|
| ORD ID | ord-f5c1479931eb4329b4b6900ca0136665 |
|---|
| Source note | uspto-grants-1999_06 |
|---|
