反应详情

In 200 ml of acetonitrile was dissolved 53 g (339 mmol) of 2,2-dichloro-3-methylbutyraldehyde (1). Then, at 0° C., 45 g of benzyloxyacetaldehyde (2c)and 400 ml of aqueous ammonia (28%)were added. The mixture was stirred at room temperature for 15 hours. This reaction mixture was concentrated under reduced pressure and the residue was extracted with methylene chloride. The extract was washed with saturated brine, dried over sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure to provide 2-(benzyloxymethyl)-4-isopropyl-1H-imidazole (3c). Yield 77 g (98.5%).

1. concentrationThis reaction mixture was concentrated under reduced pressure
2. extractionthe residue was extracted with methylene chloride
3. washThe extract was washed with saturated brine
4. dry with materialdried over sodium sulfate
5. filtrationfiltered
6. concentrationThe filtrate was concentrated under reduced pressure