Dichloromethane methanol → HCID 178425336, compound

Participants

Reaction Steps

Heated was a solution of 7.0 g (3.2 mmol)of 5-(3,5-dimethylphenylthio)-2-methyl-1H-imidazole (5b)in 37% aqueous formaline (20 ml)at 120° C. for 15 hours in a sealed tube. The reaction mixture was dissolved in methanol/methylene chloride, and the aqueous layer was separated off. The organic layer was dried over sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel chromatography (methanol:ethyl acetate=2:98), and the crude product was washed with isopropyl ether to obtain 1.7 g of [5-(3,5-dimethylphenylthio)-2-methyl-1H-imidazol-4-yl]methanol (41d)(yield 21%). mp 199-201° C.

Provenance & Evidence