Potassium Cyanide → HCID 22130162, compound

Participants

Reaction Conditions

Reaction Steps

In 5.6 ml of dry dimethylformamide was dissolved 280 mg (1.0 mmol)of 4-chloromethyl-1,2-dimethyl-5-(3,5-dimethylphenylthio)-1H-imidazole (42c). Added was 98 mg (1.5 mmol)of potassium cyanide, and the mixture was heated at 50° C. for 5 hours. To the reaction mixture, ice-water was added, extracted with diethyl ether, the extract was washed with water and dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel chromatography (ethyl acetate)to obtain 114 mg of [1,2-dimethyl-5-(3,5-dimethylphenylthio)-1H-imidazol-4-yl]acetonitrile (42d)(yield 42%). mp 81-82° C.

Provenance & Evidence