Dichloromethane → Tert-butyl 4-fluoro-4-phenylpiperidine-1-carboxylate

HRID 141610Notes

Reaction equation

HRID 141610 reaction equation
[CH2:1]([N:2]([S:3]([F:4])([F:5])[F:7])[CH2:6][CH3:8])[CH3:9].[Cl:30][CH2:31][Cl:32].[OH:10][C:11]1([c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1>>[F:7][C:11]1([c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 123472(Diethylamino)sulfur trifluorideHCID 11231242Tert-butyl 4-hydroxy-4-phenylpiperidine-1-carboxylate

Product 1

HCID 59050060Tert-butyl 4-fluoro-4-phenylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-b47602a2815145a2bd8dbc8fb71878ac
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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