反应详情

To a vigorously stirred slurry of zinc dust (6.49 g) in acetic acid (50 ml) cooled to 10° C., was added a slurry of 1-(4-Methoxybenzyl)-5-phenyl-3-(phenylhydrazono)-1,5-dihydrobenzo [b] [1,4] diazepine-2,4-dione (5.75 g,12.1 mmol) in acetic acid (30 ml) over a fifteen minute period. After complete addition, the solution was warmed to room temperature and stirred three hours. The zinc was separated by filtration and washed with ethyl acetate (75 ml). The filtrate was concentrated in vacuo and partitioned between H2O (60 ml) and ethyl acetate (100 ml). The pH was adjusted to 9 with saturated aqueous sodium carbonate and the phases separated. The aqueous phase was extracted with ethyl acetate (2×75 ml), the organic layers combined, dried with magnesium sulfate, filtered and concentrated in vacuo to give a yellow oil which was dried in vacuo to give the title compound (4.79 g) NMR (300 MHz, CDCl3): d 3.05 (s, 2H), 3.75 (s, 3H), 4.35 (s, 1H), 4.64 (d, J=14.7 Hz, 1H), 5.82 (d, J=14.7 Hz, 1H), 6.59-6.85 (m, 6H), 7.06-7.29 (m, 6H), 7.51 (d, J=7.4 Hz, 1H); MS (FAB): m/z=388.2 (MH+); TLC (CH2Cl2 /CH3OH (9:1)): Rf =0.50

1. additionAfter complete addition
2. customThe zinc was separated by filtration
3. washwashed with ethyl acetate (75 ml)
4. concentrationThe filtrate was concentrated in vacuo
5. custompartitioned between H2O (60 ml) and ethyl acetate (100 ml)
6. customthe phases separated
7. extractionThe aqueous phase was extracted with ethyl acetate (2×75 ml)
8. dry with materialdried with magnesium sulfate
9. filtrationfiltered
10. concentrationconcentrated in vacuo
11. customto give a yellow oil which
12. customwas dried in vacuo