Formic Acid → HCID 178442153, compound

HRID 1416126Notes

Reaction equation

HRID 1416126 reaction equation
[CH2:1]([CH:6]1[CH2:11][CH2:10][CH:9]([C@@H:12]2[CH2:17][O:16][C@@H:15]([CH2:18][OH:19])[O:14][CH2:13]2)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].Br[C:21](Br)([F:23])[F:22].[CH:25](O)=O>>[F:22][C:21]([F:23])=[CH:25][O:19][CH2:18][C@H:15]1[O:16][CH2:17][C@H:12]([CH:9]2[CH2:8][CH2:7][CH:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:11][CH2:10]2)[CH2:13][O:14]1

Participants

4

Reactant 3

HCID 284Formic AcidHCID 6382DibromodifluoromethaneHCID 178442154HCID 178442154, compound

Product 1

HCID 178442153HCID 178442153, compound

Procedure

27.0 g of trans/trans-[5-(4-pentylcyclohexyl)-1,3-dioxan-2-yl]methanol are firstly esterified using formic acid as described in Example 1 and then treated with dibromodifluoromethane. Conventional work-up gives trans/trans-2-(2,2-difluorovinyloxymethyl)-5-(4-pentylcyclohexyl)-1,3-dioxane.

Sources & evidence

ORD record
ord-e87c6b9aa41a442ea3837bec8747284f
Source dataset
uspto-grants-1999_06
Patent number
US05911912

Reaction notes

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