Methylhydrazine → HCID 178481940, compound

HRID 1416188Notes

Reaction equation

HRID 1416188 reaction equation
[C:1]1(=O)[O:6][C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH3:12][NH:13][NH2:14]>C(O)(=O)C.O>[OH:6][C:1]1[C:2]2[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[N:13]([CH3:12])[N:14]=1

Participants

5

Reactant 2

HCID 6061MethylhydrazineHCID 6811Phthalic Anhydride

Product 1

HCID 178481940HCID 178481940, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Phthalic anhydride (7.4 g) was dissolved in hot acetic acid (50 ml) and a solution of methylhydrazine (2.7 ml) in water (50 ml) was added. The mixture was heated under reflux for 15 minutes and left to cool overnight. The precipitate that formed was filtered off, washed with water and dried under reduced pressure at 65° C. to yield 1,2-dihydro-4-hydroxy-2-methyl-1-oxophthalazine (7.6 g) as a white solid. m.p. 243-244° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 15 minutes
  3. waitleft
  4. temperatureto cool overnight
  5. customThe precipitate that formed
  6. filtrationwas filtered off
  7. washwashed with water
  8. customdried under reduced pressure at 65° C.

Sources & evidence

ORD record
ord-2195030b280849c0ad4898b2d92d0cd3
Source dataset
uspto-grants-1999_06
Patent number
US05912244

Reaction notes

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