4-(3-chloropropoxy)-1H-indole → HCID 67573981, compound

HRID 1416202Notes

Reaction equation

HRID 1416202 reaction equation
[NH:1]1[C:9]2[C:4](=[C:5]([O:10][CH2:11][CH2:12][CH2:13]Cl)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[OH:15][C:16]1([C:22]2[CH:31]=[CH:30][C:29]3[C:24](=[CH:25][CH:26]=[C:27]([O:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH:28]=3)[CH:23]=2)[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[NH:1]1[C:9]2[C:4](=[C:5]([O:10][CH2:11][CH2:12][CH2:13][N:19]3[CH2:20][CH2:21][C:16]([OH:15])([C:22]4[CH:31]=[CH:30][C:29]5[C:24](=[CH:25][CH:26]=[C:27]([O:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH:28]=5)[CH:23]=4)[CH2:17][CH2:18]3)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 116941694-(3-chloropropoxy)-1H-indoleHCID 53734018HCID 53734018, compound

Product 1

HCID 67573981HCID 67573981, compoundYield 32.3%

Procedure

Beginning with 0.257 gm (1.2 mMol) 1-(4-indolyloxy)-3-chloropropane and 0.400 gm (1.2 mMol) 4-hydroxy-4-(6-hexyloxynaphth-2-yl)piperidine, 0.194 gm (32%) of the title compound was recovered as a white solid by the procedure described in Example 1.

Sources & evidence

ORD record
ord-6f2769c8dacc4a69a9b6d9cb73a7335b
Source dataset
uspto-grants-1999_06
Patent number
US05912256

Reaction notes

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