HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2s)-Glycidyl indol-4-yl ether → (2S)-(-)-1-(4-indolyloxy)-3-[4-hydroxy-4-(6-benzyloxynaphth-2-yl)piperidine-1-yl]-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| Reactant | 4-Hydroxy-4-(6-benzyloxynaphth-2-yl)piperidine | HCID 54231929 | — |
| Product | (2S)-(-)-1-(4-indolyloxy)-3-[4-hydroxy-4-(6-benzyloxynaphth-2-yl)piperidine-1-yl]-2-propanol | HCID 67573992 | 83% |
Reaction Steps
Beginning with 0.170 gm (0.90 mmol) (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 0.300 gm (0.90 mMol) 4-hydroxy-4-(6-benzyloxynaphth-2-yl)piperidine, 0.388 gm (83%) of the title compound were recovered as a white solid by the procedure described in Example 9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05912256 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-19f80b60d40b4dd8aa3d11701a3ac5a2 |
| Source note | uspto-grants-1999_06 |