Potassium Hydroxide → HCID 17137380, compound

Participants

Reaction Steps

2-Amino-5-mercapto-1,3,4-thiadiazole (4.0 g), dipiperidinoethylchloridehydrochloride (6.0 g), and potassium hydroxide (3.4 g) were stirred in methanol (100 ml) overnight at room temperature. The reaction mixture was concentrated under a vacuum. The residue, with water added thereto, was extracted with ethyl acetate. The extract was dried over sodium sulfate anhydride, and then concentrated under a vacuum. The resulting solid was recrystallized from n-hexane/ethanol, thereby yielding 6.1 g of the aimed compound.

Provenance & Evidence