1-Bromo-2-methylpropane → 5-[(2-Methylpropyl)thio]-1,3,4-thiadiazol-2-amine

HRID 1416220Notes

Reaction equation

HRID 1416220 reaction equation
[NH2:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1.[CH2:8](Br)[CH:9]([CH3:11])[CH3:10].[OH-].[K+]>CO>[NH2:1][C:2]1[S:3][C:4]([S:7][CH2:8][CH:9]([CH3:11])[CH3:10])=[N:5][N:6]=1

Participants

5

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 14797Potassium HydroxideHCID 178509208HCID 178509208, compound

Product 1

HCID 5839535-[(2-Methylpropyl)thio]-1,3,4-thiadiazol-2-amineYield 38.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Amino-5-mercapto-1,3,4-thiadiazole (2.0 g), isobutyl bromide (2.1 g), and potassium hydroxide (0.8 g) were stirred in methanol (50 ml) overnight at room temperature. The reaction mixture was concentrated under a vacuum. The residue, with water added thereto, was extracted with ethyl acetate. The extract was dried over sodium sulfate anhydride, and then concentrated under a vacuum. The resulting solid was recrystallized from n-hexane/ethanol, thereby yielding 1.1 g of the aimed compound.

Workup

  1. concentrationThe reaction mixture was concentrated under a vacuum
  2. additionThe residue, with water added
  3. extractionwas extracted with ethyl acetate
  4. dry with materialThe extract was dried over sodium sulfate anhydride
  5. concentrationconcentrated under a vacuum
  6. customThe resulting solid was recrystallized from n-hexane/ethanol

Sources & evidence

ORD record
ord-58e0e1e1c5f74f8980a902bb6580c64a
Source dataset
uspto-grants-1999_06
Patent number
US05912258

Reaction notes

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