HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1416241Generated: November 2, 2026
Piperazine → 4-(Piperazin-1-yl)benzene-1-sulfonamide
https://huagongshe.com/reaction/1416241
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 4-Fluorobenzenesulfonamide | HCID 120231 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(Piperazin-1-yl)benzene-1-sulfonamide | HCID 901897 | 96.1% |
Reaction Steps
A mixture of 4-fluorobenzenesulfonamide (6.95 g) and piperazine (17.1 g) in 30 mL of water is heated at 100° C. overnight. The solid is then collected, washed with water and toluene, and dried under reduced pressure to give 9.2 g of 4-(piperazin-1-yl)benzenesulfonamide; mp 219-221° C.; ms m/z 241; IR (mineral oil) 1160, 822, 1332, 608, 1593, 1137 cm-1. 1H NMR (DMSOd6) δ2.81. 3.17 2.3 7.01. 7.07.7.61.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05912246 |
|---|
| Source dataset | uspto-grants-1999_06 |
|---|
| ORD ID | ord-054c222952c249d992143eed29188b21 |
|---|
| Source note | uspto-grants-1999_06 |
|---|
