Ethylene Glycol → HCID 15409147, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(chloromethyl)imidazo[1,2-a]pyridine (0.495 g), 4-(piperazin-1-yl) benzenesulfonamide (0.717 g), triethylamine (0.456 mL), and ethylene glycol (6 mL) is stirred at 80° C. for 1.5 h. After cooling, water is added and the resulting solid is collected and washed with water and toluene. Chromatography on silica gel using methanol/dichloromethane (6/94) yields 0.69 g of the title compound; mp 238-242° C.; IR (mineral oil) 1150, 1152, 1331, 1308, 1508 cm-1. 1H NMR (DMSOd6) δ2.61. 3.28, 3.66, 6.86, 7.02, 7.06, 7.20, 7.49, 7.61, 7.85, 8.50.

Provenance & Evidence