反应详情

Following the general procedure of Example 11 and making noncritical variations, 6-chloro-2-(chloromethyl)imidazo[1,2-α]pyridine (Example 4. Step 1; 0.289 g) and 1-(2-chlorophenyl)piperazine monohydrochloride (Aldrich; 0.381 g) give, after crystallization from ethyl acetate/hexane, 0.2423 g of the title compound; mp 123-123.5° C.; MS m/z 360; IR (mineral oil) 1325, 1475, 1039, 2818, 2810 cm-1 ; 1H NMR (CDCl3) δ2.77, 3.12, 3.79, 6.96, 7.04, 7.12, 7.21, 7.34. 7.52. 8.14.

1. customgive
2. customafter crystallization from ethyl acetate/hexane, 0.2423 g of the title compound