HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-[4-[(6-Bromoimidazo[1,2-a]pyridin-2-yl)methyl]-1-piperazinyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(1-Piperazinyl)benzamide | HCID 11106509 | — |
| Reactant | 6-Bromo-2-(chloromethyl)imidazo[1,2-a]pyridine | HCID 11622894 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 4-[4-[(6-Bromoimidazo[1,2-a]pyridin-2-yl)methyl]-1-piperazinyl]benzamide | HCID 19367123 | 48.4% |
Reaction Steps
Following the general procedure of Example 2, Step 3, and making noncritical variations, 6-bromo-2-(chloromethyl)imidazo[1,2-a]pyridine (Example 15, Step 1; 0.252 g), 4-(piperazin-1-yl)benzamide (Example 3, Step 1; 0.211 g), triethylamine (0.104 g), and ethylene glycol (2 mL) give 0.206 g of the title compound after crystallization from methanol/dichloromethane/hexane; mp 238-239° C.; MS m/z 413,415; IR (mineral oil) 1612, 1656, 3379, 1331, 1240 cm-1. 1H NMR (DMSO-d6) δ2.60, 3.25, 3.66, 6.92, 7.04, 7.32, 7.49, 7.71, 7.73, 7.83, 8.87.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05912246 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-8bbaa87f0ea44346ac2dc685f601af60 |
| Source note | uspto-grants-1999_06 |