HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 19367144, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-Chloro-2-(chloromethyl)imidazo[1,2-a]pyridine | HCID 4868389 | — |
| Reactant | Piperazine, 1-(4-chlorophenyl)-, hydrochloride (1:2) | HCID 12212341 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | HCID 19367144 | HCID 19367144 | 57.1% |
Reaction Steps
Following the general procedure of Example 11 and making noncritical variations, 6-chloro-2-(chloromethyl)imidazo[1,2-a]pyridine (Example 4, Step 1; 0.354 g), 1-(4-chlorophenyl)piperazine dihydrochloride (Aldrich; 0.475 g), triethylamine (0.552 g), and ethylene glycol (2 mL) give 0.363 g of the title compound after chromatography (silica gel, methanol/dichloromethane, 4/96) and crystallization from dichloromethane/hexane; mp 145-146° C.; MS m/z 360; IR (mineral oil) 823, 1500, 1496, 1225, 814 cm-1. 1H NMR (CDCl3) δ2.72, 3.19, 3.76, 6.83, 7.13, 7.19, 7.52, 7.53, 8.14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05912246 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-4afe1f52826345c5a6efad3d90f3043e |
| Source note | uspto-grants-1999_06 |