1-Phenylpiperazinium chloride → HCID 19367125, compound

Participants

Reaction Steps

Following the general procedure of Example 11 and making non-critical variations, 6-chloro-2-(chloromethyl)imidazo[1,2-α]pyridine (Example 4, Step 1; 0.296 g) and 1-phenylpiperazine hydrochloride (Aldrich; 0.333 g) are converted to 0.279 g of the title compound after chromatography on silica gel and crystallization from dichloromethane/ethyl ether/hexane; mp 128.5-130.5° C.; MS m/z 326, 328; IR (mineral oil) 1217, 1073, 1501, 921, 1600 cm-1 ; 1H NMR (CDCl3) δ2.74, 3.24, 3.77, 6.85, 6.92, 7.12, 7.26. 7.52. 8.13.

Provenance & Evidence