1-(3,4-Dichlorophenyl)piperazine → HCID 19367101, compound

Participants

Reaction Steps

Following the general procedure of Example 11 and making non-critical variations, 6-chloro-2-(chloromethyl)imidazo[1,2-α]pyridine (Example 4, Step 1; 0.493 g) and 1-(3,4-dichlorophenyl)piperazine (Aldrich; 0.636 g) are converted to 0.404 g of the title compound after chromatography on silica gel and crystallization from ethyl ether/hexane; mp 122.5-123.5° C.; MS m/z 394; IR (mineral oil) 1339, 1488, 804, 1072, 2807 cm-1 ; 1H NMR (CDCl3) δ2.72, 3.21, 3.77, 6.72, 6.94, 7.13, 7.26, 7.52, 8.14.

Provenance & Evidence