6-Chloro-2-(chloromethyl)imidazo[1,2-a]pyridine → HCID 19367132, compound

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Reaction Steps

Following the general procedure of Example 11 and making non-critical variations, 6-chloro-2-(chloromethyl)imidazo[1,2-α]pyridine (Example 4, Step 1; 0.292 g) and 5-chloro-2-(piperazin-1-yl)benzonitrile (0.385 g) are converted to 0.349 g of the title compound after chromatography on silica gel and crystallization from ethyl ether/dichloromethane/hexane. mp 191-191.5° C.; MS m/z 385, 387; IR (mineral oil) 1486, 1330, 806, 1495, 826 cm-1 ; 1H NMR (CDCl3) δ2.77, 3.24, 3.78, 6.93, 7.12, 7.42, 7.51, 8.14.

Provenance & Evidence