反应详情

Following the general procedure of Example 9, Step 2, and making non-critical variations, 2-(chloromethyl)-6-methylimidazo[1,2-α]pyridine (Example 9, Step 1; 0.2792 g) and 5-chloro-2-(piperazin-1-yl)benzonitrile (Example 32, Step 1; 0.4029 g) give 0.176 g of the title compound after chromatography and crystallization from ethyl ether/dichloromethane; mp 135-136° C.; MS m/z 365, 367; IR (mineral oil) 1486, 803, 1341, 825, 1333 cm-1 ; 1H NMR (CDCl3) δ2.31, 2.78, 3.25, 3.77, 6.92, 7.00, 7.39-7.50, 7.86.