Piperazin-4-ylacetophenone → HCID 19367137, compound

Participants

Reaction Steps

Following the general procedure of Example 39, Step 2, 6-chloro-2-(chloromethyl) imidazo[1,2-α]pyridine (Example 4. Step 1; 0.294 g), 4-piperazinoacetophenone (Aldrich; 0.366 g), and THF (3 mL) are converted to product, which is chromatographed on silica gel using methanol/dichlormethane (2/98), followed by crystallization from ethyl acetate/dichloromethane, to give 0.270 g of the title compound in two crops; mp 185.5-187° C.; MS m/z 368; IR (mineral oil) 1600, 1661, 1252, 1327, 1197 cm-1 ; 1H NMR (CDCl3) δ2.52, 2.72, 3.40, 3.76, 6.86, 7.13, 7.52, 7.54, 7.86, 8.15.

Provenance & Evidence