1-[4-(2-Benzyloxyethoxy)-phenyl]-1-(4-benzyloxyphenyl)-4-chloro-2-phenylbut-1-ene → 4-[(Z)-4-chloro-1-[4-(2-hydroxyethoxy)phenyl]-2-phenylbut-1-enyl]phenol

HRID 1416345Notes

Reaction equation

HRID 1416345 reaction equation
C([O:8][CH2:9][CH2:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]([C:29]2[CH:34]=[CH:33][C:32]([O:35]CC3C=CC=CC=3)=[CH:31][CH:30]=2)=[C:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH2:20][CH2:21][Cl:22])=[CH:14][CH:13]=1)C1C=CC=CC=1.C(OCCOC1C=CC(/C(/C2C=CC=CC=2)=C(\C2C=CC=CC=2)/CCCl)=CC=1)C1C=CC=CC=1>>[Cl:22][CH2:21][CH2:20]/[C:19](/[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[C:18](\[C:29]1[CH:30]=[CH:31][C:32]([OH:35])=[CH:33][CH:34]=1)/[C:15]1[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][OH:8])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 536674961-[4-(2-Benzyloxyethoxy)-phenyl]-1-(4-benzyloxyphenyl)-4-chloro-2-phenylbut-1-eneHCID 70116950z-1-[4-(2-Benzyloxyethoxy)-phenyl]-4-chloro-1,2-diphenyl-but-1-ene

Product 1

HCID 30365044-[(Z)-4-chloro-1-[4-(2-hydroxyethoxy)phenyl]-2-phenylbut-1-enyl]phenol

Procedure

1-[4-(2-Benzyloxyethoxy)-phenyl]-1-(4-benzyloxyphenyl)-4-chloro-2-phenylbut-1-ene (1.0 g, 1.74 mmol) was debenzylated by the same method as Z-1-[4-(2-benzyloxyethoxy)-phenyl]-4-chloro-1,2-diphenyl-but-1-ene described in example 3. The residue was crystallised from the mixture of ethanol and water (1:1). Yield 0.3 g.

Workup

  1. customThe residue was crystallised from the mixture of ethanol and water (1:1)

Sources & evidence

ORD record
ord-dc76ab6ab441469aa50bdae2e97ddbc9
Source dataset
uspto-grants-1999_06
Patent number
US05912273

Reaction notes

Loading…