Water → HCID 178437928, compound

HRID 1416419Notes

Reaction equation

HRID 1416419 reaction equation
O.[OH-].[K+:3].[CH2:4]([C:6]1[S:10][C:9](=[N:11][C:12]([C:14]2[CH2:18][CH2:17][CH2:16][C:15]=2[C:19]([OH:21])=[O:20])=[O:13])[N:8]([CH2:22][C:23]2[CH:28]=[CH:27][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:35]3[NH:39][N:38]=[N:37][N:36]=3)=[CH:25][CH:24]=2)[N:7]=1)[CH3:5]>C(O)C>[CH2:4]([C:6]1[S:10][C:9](=[N:11][C:12]([C:14]2[CH2:18][CH2:17][CH2:16][C:15]=2[C:19]([O-:21])=[O:20])=[O:13])[N:8]([CH2:22][C:23]2[CH:24]=[CH:25][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:35]3[NH:36][N:37]=[N:38][N:39]=3)=[CH:27][CH:28]=2)[N:7]=1)[CH3:5].[K+:3].[K+:3].[CH2:4]([C:6]1[S:10][C:9](=[N:11][C:12]([C:14]2[CH2:18][CH2:17][CH2:16][C:15]=2[C:19]([O-:21])=[O:20])=[O:13])[N:8]([CH2:22][C:23]2[CH:24]=[CH:25][C:26]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[C:35]3[NH:36][N:37]=[N:38][N:39]=3)=[CH:27][CH:28]=2)[N:7]=1)[CH3:5]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 178437927HCID 178437927, compound

Product 1

HCID 178437928HCID 178437928, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a mixed solution containing 15 ml of water and 16 ml of a 0.5N potassium hydroxide solution in ethanol, 2.0 g of 2-[[5-ethyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazolin-2-yliden]aminocarbonyl]-1-cyclopentenecarboxylic acid was dissolved. From the resulting solution, the solvent was distilled off. To the residue, 50 ml of ethanol was added, and the resulting mixture was allowed to stand overnight. The crystals so precipitated were collected by filtration and dried, whereby 2.24 g of the title compound was obtained.

Workup

  1. dissolutionwas dissolved
  2. distillationFrom the resulting solution, the solvent was distilled off
  3. additionTo the residue, 50 ml of ethanol was added
  4. customThe crystals so precipitated
  5. filtrationwere collected by filtration
  6. customdried

Sources & evidence

ORD record
ord-4043fd6745a841fab045d07485c0cf4b
Source dataset
uspto-grants-1999_06
Patent number
US05912353

Reaction notes

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