Potassium Hydroxide → HCID 178437929, compound

HRID 1416420Notes

Reaction equation

HRID 1416420 reaction equation
[CH2:1]([C:3]1[S:7][C:6](=[N:8][C:9]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:16]([OH:18])=[O:17])=[O:10])[N:5]([CH2:19][C:20]2[CH:25]=[CH:24][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:36][N:35]=[N:34][N:33]=3)=[CH:22][CH:21]=2)[N:4]=1)[CH3:2].[OH-].[K+:38]>C(O)C>[CH2:1]([C:3]1[S:7][C:6](=[N:8][C:9]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:16]([O-:18])=[O:17])=[O:10])[N:5]([CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]3[NH:33][N:34]=[N:35][N:36]=3)=[CH:24][CH:25]=2)[N:4]=1)[CH3:2].[K+:38]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 178437927HCID 178437927, compound

Product 1

HCID 178437929HCID 178437929, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To 206 mg of 2-[[5-ethyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazolin-2-ylidene]aminocarbonyl]-1-cyclopentenecarboxylic acid, 8.3 ml of a 0.05N potassium hydroxide solution in ethanol and 50 ml of ethanol were added, followed by heating over water bath to dissolve completely. From the resulting solution, the solvent was distilled off under reduced pressure. To the residue, ethanol was added and the solid so precipitated was collected by filtration. The solid was dried under reduced pressure, whereby 180 mg of the title compound was obtained.

Workup

  1. temperatureby heating over water bath
  2. dissolutionto dissolve completely
  3. distillationFrom the resulting solution, the solvent was distilled off under reduced pressure
  4. additionTo the residue, ethanol was added
  5. customthe solid so precipitated
  6. filtrationwas collected by filtration
  7. customThe solid was dried under reduced pressure

Sources & evidence

ORD record
ord-8491029ced094d9aab1df2eddc24a9d9
Source dataset
uspto-grants-1999_06
Patent number
US05912353

Reaction notes

Loading…