反应详情

To 206 mg of 2-[[5-ethyl-3-[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl-1,3,4-thiadiazolin-2-ylidene]aminocarbonyl]-1-cyclopentenecarboxylic acid, 8.3 ml of a 0.05N potassium hydroxide solution in ethanol and 50 ml of ethanol were added, followed by heating over water bath to dissolve completely. From the resulting solution, the solvent was distilled off under reduced pressure. To the residue, ethanol was added and the solid so precipitated was collected by filtration. The solid was dried under reduced pressure, whereby 180 mg of the title compound was obtained.

1. temperatureby heating over water bath
2. dissolutionto dissolve completely
3. distillationFrom the resulting solution, the solvent was distilled off under reduced pressure
4. additionTo the residue, ethanol was added
5. customthe solid so precipitated
6. filtrationwas collected by filtration
7. customThe solid was dried under reduced pressure