Acetic Acid → HCID 67754208, compound

HRID 1416447Notes

Reaction equation

HRID 1416447 reaction equation
[OH:1][C@H:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:9]=1.[C:24]([OH:27])(=[O:26])[CH3:25]>C(O)C>[C:24]([OH:27])(=[O:26])[CH3:25].[OH:1][C@H:2]1[CH2:6][CH2:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[N:9]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 15409125HCID 15409125, compound

Product 1

HCID 67754208HCID 67754208, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-[cis-(2-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 3) (0.6 g) is dissolved in ethanol (10 ml), and thereto is added acetic acid (0.14 g). Undissolved material is filtered off, and the mixture is evaporated to dryness under reduced pressure. The resulting residue is further recrystallized from acetone to give 4-[cis-(2-hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (0.45 g) as crystals.

Workup

  1. filtrationUndissolved material is filtered off
  2. customthe mixture is evaporated to dryness under reduced pressure
  3. customThe resulting residue is further recrystallized from acetone

Sources & evidence

ORD record
ord-e8430cbf7dd3451cbc0a8ee968239250
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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