Acetic Acid → HCID 67582986, compound

HRID 1416453Notes

Reaction equation

HRID 1416453 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][CH:4]([O:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([N:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[N:9]=2)[CH2:3]1.[C:24]([OH:27])(=[O:26])[CH3:25]>CC(C)=O>[C:24]([OH:27])(=[O:26])[CH3:25].[OH:1][CH:2]1[CH2:6][CH2:5][CH:4]([O:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]([N:18]3[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]3)[N:9]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 53879175HCID 53879175, compound

Product 1

HCID 67582986HCID 67582986, compoundYield 68.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-[(3-Hydroxycyclopentan-1-yl)oxy]-2-(1-piperazin-yl)quinazoline (cf. Example 9) (0.55 g) is dissolved in acetone (10 ml), and thereto is added acetic acid (0.11 g), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is further recrystallized from acetone to give 4-[(3-hydroxycyclopentan-1-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (0.45 g).

Workup

  1. customthe mixture is evaporated to dryness under reduced pressure
  2. customThe resulting residue is further recrystallized from acetone

Sources & evidence

ORD record
ord-f5bb9674cecf4bfa8fff6f3cb44e1eae
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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