Acetone → HCID 67582065, compound

HRID 1416454Notes

Reaction equation

HRID 1416454 reaction equation
[OH:1][C@@H:2]1[CH2:6][O:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[N:9]=1.CC(C)=[O:26]>>[C:6]([OH:26])(=[O:5])[CH3:2].[OH:1][C@@H:2]1[CH2:6][O:5][CH2:4][C@H:3]1[O:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([N:18]2[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]2)[N:9]=1

Participants

3

Reactant 2

HCID 180AcetoneHCID 54489989HCID 54489989, compound

Product 1

HCID 67582065HCID 67582065, compound

Procedure

4-[trans-(4-Hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 11) (200 mg) is dissolved in acetone (20 ml) with heating, and the solution is filtered, and the filtrate is concentrated and thereto is added acetic acid (50 mg), and the mixture is allowed to stand at room temperature. The precipitated crystals are separated by filtration to give 4-[trans-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (171 mg).

Workup

  1. temperaturewith heating
  2. filtrationthe solution is filtered
  3. concentrationthe filtrate is concentrated
  4. additionis added acetic acid (50 mg)
  5. customto stand at room temperature
  6. customThe precipitated crystals are separated by filtration

Sources & evidence

ORD record
ord-62b23331a7244d3999cbbf9f294ee7b1
Source dataset
uspto-grants-1999_06
Patent number
US05912247

Reaction notes

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