HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 67582066, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | HCID 67582067 | HCID 67582067 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67582066 | HCID 67582066 | 70.8% |
Reaction Steps
4-[cis-(4-Hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 14) (0.95 g) is dissolved in methanol (20 ml), and thereto is added acetic acid (0.22 g), and the mixture is evaporated to dryness under reduced pressure. The resulting residue is recrystallized from acetonitrile-methanol to give 4-[cis-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline monoacetate (0.8 g) as crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05912247 |
| Source dataset | uspto-grants-1999_06 |
| ORD ID | ord-a4a06f7fa6ac4ae5b1f7019c1dfb0292 |
| Source note | uspto-grants-1999_06 |