Methanol → HCID 67582065, compound

Participants

Reaction Steps

4-[(3R,4R)-(4-Hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl)quinazoline (cf. Example 19) (758 mg) is dissolved in methanol, and the mixture is evaporated to dryness under reduced pressure. The residue is dissolved in acetone (15 ml), and the mixture is filtered, and to the filtrate is added acetic acid (202 mg), and the mixture is allowed to stand at room temperature. The precipitated crystals are separated by filtration to give 4-[(3R,4R)-(4-hydroxytetrahydrofuran-3-yl)oxy]-2-(1-piperazinyl) quinazoline monoacetate (796 mg) as crystals.

Provenance & Evidence