Triethylamine → HCID 10873678, compound

Participants

Reaction Steps

To a solution of 4-[(cyclopent-2-en-1-yl)oxy]-2-(1-piperazinyl) quinazoline (1.47 g) in dry methylene chloride (15 ml) is added triethylamine (1.39 ml) with stirring under ice-cooling, and thereto is further added dropwise a solution of benzyl chlorocarbonate (0.75 ml) in dry methylene chloride (3 ml). The mixture is stirred at 0° C. for 4 hours, and the reaction mixture is diluted with chloroform and washed with water, and then dried over anhydrous magnesium sulfate. The resulting solution is evaporated to dryness under reduced pressure, and the residue is purified by medium pressure liquid column chromatography (eluent, chloroform) to give 2-[4-(benzyloxycarbonyl)piperazin-1-yl]-4-[(cyclopent-2-en-1-yl)oxy]quinazoline (1.85 g) as crystals.

Provenance & Evidence