Water → HCID 67582094, compound

Participants

Reaction Steps

A solution of 2-[4-(benzyloxycarbonyl)piperazin-1-yl]-4-[(1R,4S)-[4-[(RS)-(tetrahydropyran-2-yl)oxy]cyclopent-2-en-1-yl]oxy]quinazoline (12.57 g) in acetic acid (50 ml)--water (12.6 ml) is stirred at 60° C. for 4.5 hours. The reaction mixture is diluted with ethyl acetate and washed with aqueous sodium hydrogen carbonate and water, and then dried over anhydrous magnesium sulfate. The solution is evaporated to dryness under reduced pressure, and the resulting residue is purified by medium pressure liquid column chromatography [eluent, chloroform, (chloroform:methanol=500:1, v/v)] to give 2-[4-(benzyloxycarbonyl) piperazin-1-yl]-4-[(1R,4S)-(4-hydroxycyclopent-2-en-1-yl) oxy] quinazoline (6.31 g) as crystals.

Provenance & Evidence